When we talk about voices and visions, we simply mean someone is hearing, seeing or sensing something that others around them aren’t.These experiences can include all five senses, hearing, sight, smell, taste and touch.
Eventually, this maxes out, and it goes and adds the receptor system for which it has the second greatest affinity. By about 20mg, you've gotten as much serotonin effect as you are going to ever get. Do you expect the clinical difference from 10mg to 20mg to be significant? The old ones-- Thorazine, Elavil, Pamelor, Remeron, Wellbutrin-- all blunt instruments, single receptor system drugs? From the Celexa package insert: (warning: PDF-- clear your schedule) 2.
A drug with affinity for multiple receptors doesn't bind to all of them simultaneously, but rather sequentially, like an aging polygamist, starting with the system for which it has the greatest affinity. That first S stands for (serotonin reuptake inhibitor.) All of its clinical effect is coming from one single receptor system; this rum fountain has only one level-- and it's not that deep. Perhaps it's because this supposedly only applies to the newer drugs?
You think I discovered all this, in my basement lab, the one I use to create Jessica Simpson clones? Why the accepted delusion that a drug is the same, regardless of dose?
So anything after 150mg is really two systems at once, with the N increasing from there.
This page contains some basic information about voices, visions and other unusual sensory perceptions.
If you feel you know little about the experience of hearing voices or seeing visions, it’s a good place to start.
However if you already know the basics and would like some more detailed information, check out the ‘About Voices‘ and ‘Personal Experiences‘ sections.
It's not adding more of the same drug, What you may want to ask is this: why haven't you heard this stuff before?
Pushing it to 60mg ("") gets you a whole 3% more serotonin transporter binding. No, because they are both doing the same thing: blocking about 80% of serotonin transporters. This is why Effexor studies only show superior efficacy at doses above 150mg-- because at 150mg, you start adding N on top of your already maxed out S.
In other words, there's only one level in Celexa's rum fountain, and it's pretty much filled by 40mg. Would you expect 75mg Effexor to be generally more efficacious than 40mg Celexa?
So what about Effexor, the serotonin/norepinephrine reuptake inhibitor, invented at Wyeth Labs by Kirsten Dunst, aka Vitamin C? You don't get both S and N at all doses, it is, again, sequential: level 1 is S, maxed out by 75mg; and level 2 is N. 300mg is the same amount of S as 150mg, but the N is more.