Sad news: Despite admitting it was not a case of 'love at first sight' when she got together with Will, it had seemed that with the 38-year-old Drew had finally found the stability she craved in life Despite counting Steven Spielberg and Sophia Loren as her god-parents, and coming from a family of successful actors, the Missing You Already star revealed that she doesn't buy into the Hollywood showbiz circuit.
We're surrounded by luxury, but Barrymore isn't interested - she's spotted my old-fashioned Dictaphone, and she is thrilled. Her clothes, like her manner, radiate ease, but on closer inspection this apparently thrown-on outfit is meticulously put-together designer. Barrymore may cultivate an easy-going, surfer-chick image but this belies an acute attention to detail, an unexpected degree of control at work in all she does.
Within seconds she is offering up high-fives and waxing lyrical about VHS tapes, typewriters, old cameras and cathode-ray-tube television sets. The more old, dusty and tainted that glass is, the prettier and more impressionistic that is to me. The jeans are in fact by Stella Mc Cartney; the shoes, Jil Sander; the jacket, Catherine Malandrino. Ever since Barrymore captivated the world as Gertie, the wide-eyed child in ET, when she was only six, she has been in the public eye.
She has been engaged three times, to the producer Leland Hayward at 16, the actor Jamie Walters and the musician Fabrizio Moretti, and married twice - once for nine weeks to a Welsh barman named Jeremy Thomas and once for five months to the comedian Tom Green.
'In my twenties I did want the fairytale,' says Barrymore today.
'But in my thirties I realised there is a next day. The irony is I don't need anyone to give the fairytale to me; I can give it to myself or I will try and provide it for people through different avenues.' More recently she has had an on-and-off relationship with Justin Long, her co-star in her new film, Going the Distance, about the trials of making a long-distance relationship work.
'I loved getting to do a film with someone that I do have a history with and we could bring a tremendous amount of honesty to it.
We sort of saw that as a surreal opportunity and maybe it will feel a little more relatable-to because it is kind of real,' she says.
Barrymore will not discuss whether they are currently together.
'I will never talk about what we do or don't do,' she says firmly.
She has starred in countless hits - including Poison Ivy, Never Been Kissed, The Wedding Singer and Batman Forever - and her production company, Flower Films, has netted more than 0 million (£560 million) thanks to projects such as Charlie's Angels, 50 First Dates and He's Just Not That Into You.
She's even triumphed in the indie market with Grey Gardens, for which she won a Golden Globe, and Donnie Darko.
It's ironic that an actress who has made such a success of the rom-com genre has found happy endings so elusive in her own life.
Barrymore has dated a host of actors, including Corey Feldman, Luke Wilson, Balthazar Getty and David Arquette.